Optimized health in a chewable tablet
WHAT ARE OXIMUNOL CHEWABLE TABLETS?
To answer this question, it might be easier to tell you what Oximunol Chewable Tablets are not:Oximunol Chewables are NOT anti-oxidants. Oximunol Chewables are NOT omega-fatty acids. Oximunol Chewables are NOT probiotics. Oximunol Chewables are NOT Vitamin A. Oximunol Chewables are NOT beta-carotene.
So what does that leave? It leaves a supplement that is truly like no other.
Oximunol Chewables are a once-a-day canine supplement containing OxC-beta as the active ingredient that, in clinical studies supported by laboratory studies, has been shown to exert its effects by priming a dog’s innate immune system leading to improved overall health.
OXC-BETA: A DIAMOND IN THE ROUGH
About 20 years ago, when other researchers were focusing on Vitamin A, which is the most well known derivative of beta-carotene, Dr. Graham Burton, leading carotenoid researcher, was moving in a different direction.
Vitamin A, as many know, is formed when the beta-carotene molecule is split in half using oxygen molecules and a special enzyme in the gut. But what about all the other compounds formed when oxygen and beta-carotene meet?
Enter OxC-beta, a complex mixture of molecules formed when beta-carotene encounters oxygen molecules and is allowed to fully oxidize.
CAROTENOIDS AND THEIR ROLE IN HEALTH
There are at least 600 known carotenoid compounds, of which about 20 are found in the human diet. Beta-carotene is one of the most abundant of these compounds and is the best known because it is a major source of vitamin A, which is obtained by a very specific, enzyme-catalyzed symmetric cleavage by oxidation of the central carbon-carbon double bond.
However, beta-carotene and several other carotenoids that are also sources of vitamin A are known to show other, non-vitamin A, biological activities, i.e., activities that cannot be reproduced by replacing the carotenoid with vitamin A (e.g., immune modulation). As well, many of the carotenoid compounds that are not sources of vitamin A have biological activities that cannot be attributed to vitamin A.
WHAT IS OXC-BETA?
OxC-beta is the proprietary, patented active ingredient in Oximunol™ Chewable Tablets. It is a highly concentrated version of oxidized derivatives of carotenoids that are found naturally and extensively in the plant world in minute amounts.
OxC-beta possesses multiple immunomodulatory activities including:* Priming of the gut innate immune function by upregulation of surveillance receptors, and; * Helping to maintain a normal inflammatory response.
This means OxC-beta possesses a unique ability to both promote the body’s innate resistance to pathogens while at the same time limiting the potential for an unregulated and harmful inflammatory cascade to arise.
HOW DOES OXC-BETA WORK?
According to clinical and laboratory studies carried out by Chemaphor by Dr. Jamie Nickerson and his team, OxC-beta has been shown to have the ability to prime an organism’s innate immune system.
A primed innate immune system means that an organism is better prepared to fend off foreign attackers such as bacteria, viruses and other harmful substances.
With less energy being expended on fighting off bad guys, the body can use that energy to keep things running at optimum levels.
Outwardly we see this as improvements in skin/coat, better regulation of inflammatory responses leading to improved mobility, optimized digestion and increased energy.
WHY USE A NATURAL HEALTH OPTIMIZER LIKE OXIMUNOL™ CHEWABLES?
* Proactive measure to help achieve optimal health
* A continuous regimen to help maintain a healthy pet
* Preventative – low level use helps body maintain optimal health by helping maintain a strong immune system.
Oximunol™ is a new, scientifically formulated unique health product containing OxC-beta that works with a dog’s own immune system to optimize overall health and well-being including:* Leads to maintenance of normal intestinal function * Promotes and supports healthy joint function * Promotes and maintains normal mobility * May help discomfort associated with normal daily activity * Enhances healthy condition of skin and coat
The tablets are chewable and have the following features:* Highly palatable beef flavour (no products of bovine origin) * Available in 5mg and 20mg sizes for precise dosing * Safe for pets on protein restricted and hypoallergenic diets Oximunol™ Chewable Tablets are highly palatable and easily administered to dogs. Two tablet sizes, 5 mg and 20 mg, allow easy and convenient dosage for all sizes of dogs.
EFFECT OF OXC-BETA IN DOGS
Research in canine fibroblasts has shown that OxC-beta treatment helps to maintain a normal cytokine cascade resulting in a healthy balance between mechanisms involved in triggering inflammation and those involved in resolving inflammation.
Fibroblasts were pre-treated with OxC-beta for 24 hours. Following pre-treatment, cells were challenged by exposure to bacterial lipopolysaccharide (LPS) for 4 hours. Chemokine expression was measured using quantitative real-time PCR with total RNA.
Results show that in the context of an LPS challenge OxC-beta has a significant suppressive effect on the level of MCP-1 (CCL2) and RANTES (CCL5) gene-expression. The suppressive effect of OxC-beta was evaluated relative to cells treated with LPS alone.
OXIMUNOL™ CHEWABLE TABLETS PALATABILITY PROVEN IN TRIALS
Studies with dogs indicate that Oximunol™ Chewable Tablets with palatability enhancer were accepted by a greater proportion of dogs (81%) compared to the positive control, Heartgard (71%).
BENEFICIAL EFFECTS PROVEN IN CLINICAL TRIAL
A clinical trial, conducted by the Chemaphor Nutrisciences Research Group in Charlottetown, Prince Edward Island, found statistically significant (P<0.05) improvement of coat quality compared to untreated controls. In addition, treated dogs showed a tendency to increased enjoyment of walks.
The study consisted of a blinded, randomized clinical trial involving 46 dogs recruited from the public. The dogs were randomly assigned to receive either the Oximunol™ Chewable Tablets (0.5 mg/kg body weight) or a placebo once daily over a period of six months. Owners completed questionnaires at the start and end of the study regarding their dog’s level of anxiety, activity, enjoyment of physical activity and coat quality.
The results indicate OxC-beta was well tolerated and may have beneficial effects as a supplement for dogs, particularly with regard to improvement of coat quality and mobility. No adverse effects were reported.
SAEETY OF OXC-BETA SUPPORTED BY CLINICAL STUDY
A recent study examined the safety of the oxidized beta-carotene (OxC-beta) in dogs treated orally once daily for 28 days at 2, 7, and 11 times the intended dose.
Results did not reveal any adverse effects based on physical examination, body weight measurement, food consumption, CBC, serum biochemistry, coagulation parameters, and urinalysis.
CONTINUING RESEARCH ON OXC-BETA
OxC-beta has been researched and developed over the last ten years. The basic idea behind OxC-beta technology is that the bioactives of carotenoids result from one or more of their oxidation products, not from the carotenoid compound itself. Intensive research is ongoing in Canada to develop scientifically documented applications in both animals and humans.
MANUFACTURED IN CANADA TO PHARMACEUTICAL CGMP STANDARDS
Avivagen has adopted a stringent regulatory standard for Oximunol™ Chewable Tablets to provide the highest level of assurance to our customers. Oximunol™ Chewable Tablets are manufactured by Pillar5 Pharma Inc., a Canadian company located in Ontario which holds an FDA Registration Establishment number and Drug Establishment License and a Natural Health Product License with Health Canada.
Avivagen has adopted a stringent regulatory standard for Oximunol™ Chewable Tablets to provide the highest level of assurance to our customers.
These quality assurance measures include:* Establishing Current Good Manufacturing Practices * Developing an Adverse Event Reporting System * Meeting labeling and claims guidelines * Being subject to an independent audit verification program